Vascular calcification in chronic kidney disease: Evolving pathogenesis with progressive chronic kidney disease?

Vascular Calcification in Chronic Kidney Disease

ialysis patients have increased cardiovascular morbidity, mortality, and vascular calcification, and the latter ppears to impact the former. Recent evidence indicates that vascular calcification is an active, cell-mediated rocess. Osteoblast differentiation factor Cbfa1 and several bone-associated proteins (osteopontin, bone sialorotein, alkaline phosphatase, type I collagen) are present in his...

Vitamin deficiencies in chronic kidney disease

Endocrine disorders in chronic kidney disease

Background and Objective: Endocrine disorders are common in patients with chronic kidney disease (CKD). The aim of the present study is reviewing available literature to give a deep understanding of complexities of endocrine disorders in chronic kidney disease. Methods: A narrative reviewing method based on the available literature was approached. Findings: Generally, when renal function de...

Matrix remodeling in vascular calcification associated with chronic kidney disease.

Vascular calcification is a major contributor to cardiovascular disease, a leading cause of death in patients with chronic kidney disease. Mechanistic studies highlight the importance of dysregulated mineral metabolism, vascular osteochondrogenic processes, apoptosis, and deficiencies in calcification inhibitors as potential mediators of calcification in renal disease. However, the contribution...

Skin autofluorescence associates with vascular calcification in chronic kidney disease.

OBJECTIVE This study aims to evaluate the relationship between tissue advanced glycation end products, as reflected by skin autofluorescence, and vascular calcification in chronic kidney disease. APPROACH AND RESULTS Three hundred patients with stage 3 to 5 chronic kidney disease underwent multislice computed tomography to estimate total coronary artery calcium score (CACS) and had tissue adv...